Foot and mouth disease (FMD) is a viral disease of cloven-hoofed animals that causes low productivity consequently, causes highly economic loses. It is an endemic disease in Kurdistan Region, Iraq. The aim of the study is to distribute the FMD cases geographically by using Geographic Information System (GIS). Besides, the study assess the geographical relationship and prevalence rate between the areas having disease in Duhok Governorate, Kurdistan Region, Iraq (DGKRI) with other areas on borders of Iraq, and neighboring countries. Data of FMD in sheep in DGKRI have been used from three years 2013, 2014 and 2015 and obtained from Directorate of Veterinary in Duhok Governorate (DVDG). The results show that the highest prevalence rate of FMD cases found in areas of Duhok adjacent to other Arabs areas or countries. Among all the three years the areas Semel and Zaxo in 2015 which are located on borders with Turkey and Syria shows the highest number of cases. Whereas, in 2014 the highest cases of FMD is in Semel and Akre. While, in 2013 the highest prevalence rate of disease is in Zummer. To sum up, the study shows that the conflicted circumstances and war in the area have affected on spreading and increasing the rate of the disease in Duhok.